IND on herbal medicine prescription for Taeeum-type approved
KIOM and Cheonan Oriental Hospital of Daejeon University set to start clinical tests
on treatment of metabolic diseases of patients in Taeeum-type
Constitutional clinical tests based on SCAT expected to increase
‘Yeoldahanso-tang’ and ‘Taeeumjowi-tang’, leading herbal medicine prescriptions suitable for people in the Taeeum-type - who take up the largest percentage among Koreans - will soon be subject to clinical tests designed to verify their effects on the treatment of metabolic diseases.
The Korea Institute of Oriental Medicine (KIOM) announced that its investigational new drug (IND) application on ‘Yeoldahanso-tang’ and ‘Taeeumjowi-tang’, jointly submitted with Cheonan Oriental Hospital of Daejeon University, was approved by the Ministry of Food and Drug Safety. The application was made as part of the project for the development of personalized treatment solutions for metabolic diseases for different constitutional types, which is sponsored by the Ministry of Science, ICT and Future Planning.
In the clinical tests, drug treatment using ‘Yeoldahanso-tang’ and ‘Taeeumjowi-tang’ will be made on patients with metabolic disorders after determining their physical constitutions based on analysis results of the Sasang Constitutional Analysis Tool (SCAT) developed by KIOM.
This marks the fist case in which an investigational new drug application incorporating the method of diagnosis of physical constitutions based on SCAT, developed by KIOM, and its utilization was approved by the Ministry of Food and Drug Safety. It also presents an opportunity for the swift expansion of constitutional clinical tests based on a constitutional analysis tool that applies IT technology.
‘Yeoldahanso-tang’ and ‘Taeeumjowi-tang’, decoctions recorded in Donguisusebowon, a major literature on constitutional medicine, are known to have significant clinical effects on various diseases related to Taeeum-type patients.
The two prescriptions were confirmed to be effective for such conditions related to lipid metabolism as hyperlipidemia, diabetes and obesity, in cellular tests and animal tests previously held. Clinical tests for the treatment of metabolic disorders of Taeeum-type patients will be held in Cheonan Oriental Hospital, the test agency.
※ Metabolic diseases include hypertension, diabetes, hyperlipidemia and obesity, and they are preceding diseases for myocardial infarction, cerebral infarction, etc. According to the 2014 Korea National Health and Nutritional Examination Survey conducted by the Ministry of Health and Welfare, one of two adults aged 30 or older in the country appeared to suffer from one or more metabolic disorders.
※ Yeoldahanso-tang is a prescription used to treat metabolic disorders caused by high body temperature in people of the Taeeum type.
※ Taeeumjowi-tang is a prescription for such conditions of Taeeum-type people as jaundice, cold and epidemic headache, and when they have sore muscles but do not sweat, have upset stomach and feel bloated, feel weak in legs and knees, or have little strength in general.
Meanwhile, as the prevalence of metabolic disorders spreads, the importance of their prevention and treatment is gradually becoming more pronounced. However, conventional drug treatment and preventive clinical applications that fail to consider the uniqueness and different physical constitutions of individual patients show limited effects. The clinical test on personalized drug treatment for different constitutional types based on Korean medicine has significance as one of the alternatives to tackle this problem.